Centrifugation is a common laboratory technique, and silicone oil plays a supportive role in enhancing accuracy and protecting equipment. Due to its stable viscosity and non-volatile nature, silicone oil is used as a cushion medium in ultracentrifuges, where delicate gradients and samples must be protected during high-speed spins.

The cushioning effect of silicone oil prevents tube breakage and reduces mechanical stress, especially when working with fragile biological materials. Its density can also be matched to specific requirements, making it suitable for use in density-gradient centrifugation.

Moreover, silicone oil’s resistance to oxidation ensures it remains effective even under prolonged operation, minimizing maintenance needs. Its compatibility with biological samples further supports its wide application in molecular biology, protein studies, and clinical laboratories.

Future developments may focus on specialized silicone oils with tunable densities to improve separation precision in advanced centrifugation methods.

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