Propolis for caries control is a kind of adhesive substance formed by the mixture of resin and other secretions of gum plants collected by worker bees and their secretions, such as Maxillary gland and wax gland. It has a wide spectrum of bacteriostatic effect and can inhibit more than 20 kinds of bacteria, such as Staphylococcus aureus, Streptococcus, Salmonella, Escherichia coli, pycnococcus aeruginosa, Candida albicans and anthrax.
Caries is a worldwide infectious disease related to public health. Its main pathogens are Streptococcus mutans, Streptococcus sobrinus, actinomycetes viscosus and Lactobacillus acidophilus, which mainly exist in dental caries. Streptococcus mutans is the most important cariogenic bacteria, and its cariogenic ability mainly comes from its adhesion ability and acid production ability. Fluoride and antimicrobial agents are often used in clinical caries prevention, but these traditional antimicrobial agents are easy to produce drug resistance and have obvious side effects in the long-term use. Therefore, the search for safe and effective natural anti caries drugs has become a research hotspot.
The anti caries effect of propolis has been confirmed by a large number of studies at home and abroad. Propolis can effectively inhibit the growth, adhesion, acid production and acid resistance of Streptococcus mutans, inhibit its glucosyltransferase activity, inhibit the formation of its biofilm, and penetrate the biofilm to act on the bacteria in the membrane, effectively remove the plaque biofilm, prevent and treat caries.
Zeng Xuening and other researchers found that propolis can affect the metabolism of Streptococcus mutans and reduce the acid production capacity of Streptococcus mutans. Wang Bing used ethyl acetate as the extraction solvent of propolis active component to determine the antibacterial effect of propolis on Streptococcus mutans. The results showed that the higher the content of flavonols in propolis, the stronger the inhibition on the growth of S.mutans, the stronger the inhibition on its acid production, and the stronger the anti caries activity.
The phenol content in propolis had no significant effect on the adhesion of S.mutans to the glass tube wall, but it was found by SEM and TEM that propolis destroyed the cell structure and cell division of S.mutans.
Yang Gensen et al. Made a clinical observation on the caries prevention effect of propolis. 241 kindergarten children aged 3-4 were randomly divided into propolis caries prevention group (taking propolis caries prevention gum every 2 days), xylitol gum control group (taking xylitol gum every 2 days) and air white control group (not taking any medicine). 2 Results the caries rate, caries and caries surface of propolis group were significantly lower than those of xylitol group and blank control group, indicating that propolis had significant caries prevention effect.
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